Inhibítory DPP-4 – v čom sú si podobné a v čom sa líšia?
Inhibítory DPP-4 – v čom sú si podobné a v čom sa líšia?
Narastajúca prevalencia diabetu typu 2 a jeho komplikácií na celom svete prináša potrebu efektívnych a bezpečných liečebných stratégií. Dôležitými perorálnymi antidiabetikami pre starostlivosť o pacientov s diabetom typu 2 sa stali inhibítory dipeptidylpeptidázy-4 (DPP-4). Všetky inhibítory DPP-4 pôsobia na inkretínový systém s cieľom znížiť hyperglykémiu, majú podobný bezpečnostný profil, sú dobre znášané, nespôsobujú významné zvýšenie telesnej hmotnosti a majú relatívne nízke riziko hypoglykémie. Medzi štyrmi agensmi, ktoré sú v súčasnosti schválené Americkým úradom pre potraviny a lieky prípadne Európskou agentúrou pre lieky, sitagliptínom, vildagliptínom, saxagliptínom a linagliptínom, sú však klinické rozdiely. Tento článok pojednáva o podobnostiach a rozdieloch v účinnosti, bezpečnosti a znášanlivosti týchto štyroch inhibítorov DPP-4.
Kľúčové slová:
inhibítory DPP-4 – vildagliptín – sitagliptín – saxagliptín – linagliptín – diabetes typu 2 – inkretínový systém – GLP-1
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Matthias Blüher
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Faculty of Medicine, University of Leipzig, Leipzig, Germany and University Hospital Leipzig, Department of Internal Medicine III - Department of endocrinology and nephrology, Leipzig, Germany
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Forum Diab 2012; 1(1): 8-16
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Topic
Narastajúca prevalencia diabetu typu 2 a jeho komplikácií na celom svete prináša potrebu efektívnych a bezpečných liečebných stratégií. Dôležitými perorálnymi antidiabetikami pre starostlivosť o pacientov s diabetom typu 2 sa stali inhibítory dipeptidylpeptidázy-4 (DPP-4). Všetky inhibítory DPP-4 pôsobia na inkretínový systém s cieľom znížiť hyperglykémiu, majú podobný bezpečnostný profil, sú dobre znášané, nespôsobujú významné zvýšenie telesnej hmotnosti a majú relatívne nízke riziko hypoglykémie. Medzi štyrmi agensmi, ktoré sú v súčasnosti schválené Americkým úradom pre potraviny a lieky prípadne Európskou agentúrou pre lieky, sitagliptínom, vildagliptínom, saxagliptínom a linagliptínom, sú však klinické rozdiely. Tento článok pojednáva o podobnostiach a rozdieloch v účinnosti, bezpečnosti a znášanlivosti týchto štyroch inhibítorov DPP-4.
Kľúčové slová:
inhibítory DPP-4 – vildagliptín – sitagliptín – saxagliptín – linagliptín – diabetes typu 2 – inkretínový systém – GLP-1
Sources
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