Diabetes mellitus and hepatitis C
Authors:
Petr Husa; Petr Husa Jr
Authors‘ workplace:
Klinika infekčních chorob LF MU a FN Brno, pracoviště Bohunice
Published in:
Forum Diab 2016; 5(3): 134-136
Category:
Foreign Post
Overview
Extrahepatic manifestations of hepatitis C virus infection (HCV) are very common. A link with the HCV infection is considered to be established with membranoproliferative glomerulonephritis, leukocytoclastic vasculitis, lymphoproliferative disorders (in particular B-cell lymphoma), Sjögren and sicca syndrome, lichen planus, porfyria cutanea tarda and diabetes mellitus. Antiviral therapy may prevent progression to diabetes in patients with prediabetes who have hepatitis C and may reduce renal and cardiovascular complications in patients with established diabetes who have hepatitis C.
Key words:
extrahepatic manifestations – chronic hepatitis C – direct acting antivirals
Sources
1. European Association for the Study of Liver. EASL recommendations on treatment of hepatitis C 2016. Summary. Dostupné z WWW: <http://www.easl.eu/medias/cpg/HCV2016/Summary.pdf>.
2. Tillmann HL, McHutchison JG. Hepatitis C. In: Boyer TD, Manns MP, Sanyal A. Zakim and Boyer´s Hepatology: A Textbook of Liver Disease. 6th ed. Elsevier Saunders: Philadelphia 2012: 574–576. ISBN 978–1437708813.
3. American Association for the study of Liver Diseases (AASLD). HCV Guidance: Recommendation for testing, managing, and treating hepatitis C. Dostupné z WWW: <http://www.hcvguidelines.org/>.
4. White DL, Ratziu V, El-Serag HB. Hepatitis C infection and risk of diabetes. A systematic review and meta-analysis. J Hepatol 2008; 49(5): 831–844. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2008.08.006>.
5. Mehta SH, Brancati FL, Sulkowski MS et al. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med 2000; 133(8): 592–599.
6. Yoneda M, Saito S, Ikeda T et al. Hepatitis C virus directly associates with insulin resistance independent of the visceral fat area in nonobese and nondiabetic patients. J Viral Hepat 2007; 14(9): 600–607.
7. Petta S, Camma C, Di Marco V et al. Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection. Am J Gastroenterol 2008; 103(5): 1136–1144. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1572–0241.2008.01813.x>.
8. Hung CH, Wang JH, Hu TH et al. Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection. World J Gastroenterol 2010; 16(18): 2265–2271.
9. Arase Y, Suzuki F, Suzuki Y et al. Sustained virological response reduces incidence of onset of type 2 diabetes in chronic hepatitis C. Hepatology 2009; 49(3): 739–744. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.22703>.
10. Hsu YC, Lin JT, Ho HJ et al. Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients. Hepatology 2014; 59(4): 1293–1302. Dostupné z DOI: <http://dx.doi.org/10.1002/hep.26892>.
11. Hsu YC, Ho HJ, Huang YT et al. Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection. Gut 2015; 64(3): 495–503. Dostupné z DOI: <http://dx.doi.org/10.1136/gutjnl-2014–308163>.
12. University of Liverpool. Drug interactions charts. Dostupné z WWW: <http://www.hep-druginteractions.org/>.
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Forum Diabetologicum
![Issue 3](https://www.forumdiabetologicum.sk/media/cache/resolve/journal_issue/media/image_pdf/0832c5b8c37e2acd510e081515b0172e.jpeg)
2016 Issue 3
Most read in this issue
- Diabetes mellitus and secondary immunodeficiency
- Chronic obstructive pulmonary disease, metabolic syndrome and diabetes mellitus
- An infection of the urogenital tract in female patients with diabetes
- Assessment of the development of head and neck infections – comparison of cohorts of patients with and without diabetes mellitus