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Practical experience confirms the results of the RCT and RWE studies with empagliflosin: case reports

Czech version

Authors: Emil Martinka 1,2;  Daniela Kollárová 3;  Monika Urbanová 4
Authors‘ workplace: Národný endokrinologický a diabetologický ústav, n. o., Ľubochňa 1;  Fakulta zdravotníckych vied Piešťany, Univerzita Sv. Cyrila a Metoda, Trnava 2;  DK ORTOPÉDIA s. r. o., Nové Zámky 3;  TabletkaDia, s. r. o., Nitra 4
Published in: Forum Diab 2021; 10(1): 53-61

Overview

SGLT2 Cotransporter (SGLT2i) Inhibitors is a relatively new group of pharmaceuticals that have been developed as oral antidiabetics to control elevated blood glucose levels. A unique feature of SGLT2i is that they achieve a decrease in glycemia independently of insulin secretion and tissue sensitivity to insulin, by blocking the reabsorption of glucose from primary urine in the proximal renal tubule and its subsequent excretion into the urine. Initial concerns about side effects - in particular the risk of genitourinary infections, dehydration or loss of electrolytes and minerals - have finally not been proven as limiting the use of these drugs. Quite the reverse, randomized controlled trials (RCTs) to assess the cardiovascular safety of individual SGLT2i molecules have demonstrated not only safety but even cardiovascular benefit. We present two case reports from diabetological outpatient clinics concerning patients whose treatment was intensified by the addition of SGLT2i empagliflozin. Experience of both the case reports indicates consistency with the published results of the large RCT and RWE studies, stating that the addition of empagliflozin to treatment contributes not only to the significant control of glycemias and body weight, but also to a significant reduction of morbidity-mortality, cardiovascular and renal risk.

Keywords:

antidiabetic drugs – empagliflozin – inhibitors SGLT2 – glucose concentrations

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