Metabolic syndrome and chronic kidney disease
Authors:
Adrián Okša
Authors‘ workplace:
Lekárska fakulta SZU v Bratislave
Published in:
Forum Diab 2023; 12(2): 65-67
Category:
Overview
Metabolic syndrome (MS) is a complex of interrelated risk factors for cardiovascular disease and type 2 diabetes mellitus. Several studies have also confirmed the association between MS and chronic kidney disease (CKD). The basis of MS is insulin resistance and metabolically induced inflammation in the expansion of visceral adipose tissue. Other pathogenetic factors in renal damage are imbalance in adipokine production, activation of the renin-angiotensin- aldosterone system and the sympathetic nervous system, increased endothelin 1 concentration, mitochondrial dysfunction, oxidative stress, and compression of the renal parenchyma due to accumulation of perirenal fat. These factors result in glomerular hyperfiltration, endothelial dysfunction, podocyte damage, mesangial expansion, glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Elucidating the mechanisms by which MS induces renal damage is crucial to prevent the onset and progression of CKD.
Keywords:
metabolic syndrome – insulin resistance – chronic kidney disease – visceral obesity – metabolically induced inflammation – mitochondrial dysfunction
Sources
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Labels
Diabetology Endocrinology Internal medicineArticle was published in
Forum Diabetologicum
2023 Issue 2
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