Folistatin and type 2 diabetes mellitus
Authors:
Patrik Valent; Andrej Dukát
Authors‘ workplace:
V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava
Published in:
Forum Diab 2024; 13(1): 47-50
Overview
Follistatin is a recently discovered hepatokine that binds and neutralizes members of transforming growth factor β family (TGFβ). It has significance in reproductive actions, intrauterine development, building and maintaining muscle mass during regeneration and fasting, nevertheless mainly in regulation of metabolic pathways. Its association with type 2 diabetes (T2D) was besides other studies confirmed by two cohort studies: Swedish during 19-year follow-up (n = 4 060) and Finnish during 4-year follow-up (n = 883). Both demonstrated its potential to be a new early predictive biomarker for T2D. In patients with diabetic cardiomyopathy showed up its protective effect with capability to regress cardial dysfunction and reduce myocardial fibrosis. Latest researches opens up the issue of therapeutical usage of follistatin in diabetes with its change of expression for improvement of glucose uptake and increased insulin sensivity in tissues.
Keywords:
type 2 diabetes mellitus – biomarker – follistatin – hepatokine
Sources
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