Metformin in patients with psoriasis

Czech version

Authors: Martin Jozef Péč ¹; Jakub Jurica ¹; Monika Péčová ²; Matej Samoš ^1,3; Peter Galajda ¹; Marián Mokáň ¹
Authors‘ workplace: I. interná klinika JLF UK a UNM, Martin ¹; Onkologické centrum a Klinika hematológie a transfuziológie JLF UK a UNM, Martin ²; Oddelenie akútnej kardiológie SÚSCCH a. s., Banská Bystrica ³
Published in: Forum Diab 2024; 13(1): 37-41

Overview

Metformin is the gold standard for the treatment of type 2 diabetes mellitus. However, it has been shown to have potential benefits for psoriasis patients as well. Metformin, in addition to its hypoglycemic effect, has demonstrated a direct anti-inflammatory effect through activation of adenosine monophosphate-activated protein kinase and inhibition of inflammatory cytokines. Studies suggest that metformin can improve symptoms of psoriasis and metabolic syndrome, showing even greater results when combined with other treatment modalities. Additional evidence suggests a possible prevention of the development of psoriasis in diabetic patients, and its combined use with other drugs may lead to improved quality of life and reduced cardiovascular risk factors. At the same time, studies have shown the safety of metformin in patients with psoriasis. However, further randomized clinical trials are needed to confirm its effectiveness and role in the treatment of psoriasis.

Keywords:

metformin – metabolic syndrome – Psoriasis – type 2 diabetes mellitus

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Article was published in

Forum Diabetologicum

2024 Issue 1