Sodium-glucose cotransporter 2 inhibitors in patients with chronic kidney disease without and after kidney transplantation
Authors:
Patrícia Kleinová 1,2; Tímea Blichová 1,2; Matej Vnučák 1,2; Karol Graňák 1,2; Monika Beliančinová 1,2; Ivana Dedinská 1,2
Authors‘ workplace:
Transplantačno-nefrologické oddelenie UNM, Martin
1; I. interná klinika JLF UK a UNM, Martin
2
Published in:
Forum Diab 2024; 13(2): 69-72
Category:
Review Article
Overview
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) represent the first-line treatment for diabetic kidney disease, and have also become part of the treatment algorithm for chronic kidney disease. Gliflozin have significant cardio-renoprotective effects with reduction of albuminuria and stabilization of glomerular filtration rate in patients with chronic kidney disease. Secondary effects (weight reduction, stimulation of erythropoiesis, inhibition of pro-inflammatory parameters) make SGLT2i broad-spectrum agents with the possibility of expanding prescribing restrictions. However, the benefit and safety of use in patients after kidney transplantation remains a question.
Keywords:
kidney transplantation – chronic kidney disease (CKD) – sodium-glucose cotransporter 2 inhibitors (SGLT2i)
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Labels
Diabetology Endocrinology Internal medicineArticle was published in
Forum Diabetologicum
2024 Issue 2
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