#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Transplantation of the islets of Langerhans – present and future. First experience with islet of Langerhans transplantation in Slovakia


Authors: Ingrid Dravecká 1;  Igor Gala 2;  Tatiana Baltesová 2;  Luboslav Beňa 2;  Štefan Hulík 3;  Peter Girman 4
Authors‘ workplace: I. interná klinika LF UPJŠ a UNLP, Košice 1;  Transplantačné oddelenie UNLP, Košice 2;  I. chirurgická klinika LF UPJŠ a UNLP, Košice 3;  Centrum diabetologie IKEM, Praha 4
Published in: Forum Diab 2024; 13(2): 79-89
Category: Review Article

Overview

Diabetes mellitus is a complex metabolic disease with impaired insulin secretion. The standard treatment for auto­immune type 1 diabetes is basal-bolus insulin administration or insulin pump therapy. Other treatment alternatives include transplantation of the islets of Langerhans (LO). Despite its effectiveness, it cannot be performed universally, due to the lack of donors and the need for immunosuppression. Current opportunities in stem cell transplantation provide an alternative to LO transplantation. Despite their therapeutic potential, the clinical viability of transplanted stem cells presents many challenges, including maturation, rejection and survival. Although cells are currently transplanted into the portal vein in the liver, it appears that the hepatic environment may not be suitable for LO function and long-term survival of not only cadaveric but also stem cells. Therefore, it is important to improve the efficiency of transplanted islets by developing biomaterials and using other transplantation sites with better graft survival. In 2023, the first successful allogeneic transplantation of islets of Langerhans in Slovakia was performed at UNLP in Košice in collaboration with IKEM in Prague.

Keywords:

type 1 diabetes – immunosuppression – encapsulation – islets of Langerhans – stem cells -transplantation


Sources

Rickels MR, Robertson RP. Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions. Endocr Rev 2019; 40(2): 631–668. Dostupné z DOI: <http://dx.doi.org/10.1210/er.2018–00154>.

Czarnecka Z, Dadheech N, Razavy H et al. The Current Status of Allogenic Islet Cell Transplantation. Cells 2023; 12(20): 2423. Dostupné z DOI: <http://dx.doi.org/10.3390/cells12202423>.

Shapiro AM, Pokrywczynska M, Ricordi C. Clinical pancreatic islet transplantation. Nat Rev Endocrinol 2017; 13(5): 268–277. Dostupné z DOI: <http://dx.doi.org/10.1038/nrendo.2016.178>.

Cayabyab F, Nih LR, Yoshihara E. Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes. Front Endocrinol (Lausanne) 2021; 12: 732431. Dostupné z DOI: <http://dx.doi.org/10.3389/fendo.2021.732431>.

Noguchi H, Naziruddin B, Jackson A et al. Fresh islets are more effective for islet transplantation than cultured islets. Cell Transplant 2012; 21(2–3): 517–523. Dostupné z DOI: <http://dx.doi.org/10.3727/096368911X605439>.

Sutherland DE, Gruessner AC, Carlson AM et al. Islet autotransplant outcomes after total pancreatectomy: a contrast to islet allograft outcomes. Transplantation 2008; 86(12): 1799–1802. Dostupné z DOI: <http://dx.doi.org/10.1097/TP.0b013e31819143ec>.

Chung WY, Pollard CA, Kumar R et al. A Comparison of the Inflammatory Response Following Autologous Compared with Allogenic Islet Cell Transplantation. Ann Transl Med 2021; 9(2): 98. Dostupné z DOI: <http://dx.doi.org/10.21037/atm-20–3519>.

Komatsu H, Kandeel F, Mullen Y. Impact of Oxygen on Pancreatic Islet Survival. Pancreas 2018; 47(5): 533–543. Dostupné z DOI: <http://dx.doi.org/10.1097/MPA.0000000000001050>.

Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343(4): 230–238. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJM200007273430401>.

Buitinga M, Truckenmüller R, Engelse MA et al. Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans. PLoS One 2013; 8(5): e64772. Dostupné z DOI: <http://dx.doi.dorg/10.1371/journal.pone.0064772>.

Ryan EA, Lakey JR, Paty BW et al. Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes 2002; 51(7): 2148–2157. Dostupné z DOI: <http://dx.doi.org/10.2337/diabetes.51.7.2148>.

Ryan EA, Paty BW, Senior PA et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54(7): 2060–2069. Dostupné z DOI: <http://dx.doi.org/10.2337/diabetes.54.7.2060>.

Gamble A, Pepper AR, Bruni A et al. The journey of islet cell transplantation and future development. Islets 2018; 10(2): 80–94. Dostupné z DOI: <http://dx.doi.org/10.1080/19382014.2018.1428511>.

Berney T, Wassmer CH, Lebreton F et al. From islet of Langerhans transplantation to the bioartificial pancreas. Presse Med 2022; 51(4): 104139. Dostupné z DOI: <http://dx.doi.org/10.1016/j.lpm.2022.104139>.

Bouwens L, Houbracken I, Mfopou JK. The use of stem cells for pancreatic regeneration in diabetes mellitus. Nat Rev Endocrinol 2013; 9(10): 598–606. Dostupné z DOI: <http://dx.doi.org/10.1038/nrendo.2013.145>.

Gan SU, Notaridou M, Fu ZY et al. Correction of Murine Diabetic Hyperglycaemia With A Single Systemic Administration of An AAV2/8 Vector Containing A Novel Codon Optimized Human Insulin Gene. Curr Gene Ther 2016; 16(11): 65–72. Dostupné z DOI: <http://dx.doi.org/10.2174/1566523216666160122113958>.

Cuesta-Gomez N, Verhoeff K, Jasra IT et al. Characterization of stem-cell-derived islets during differentiation and after implantation. Cell Rep 2022; 40(8): 111238. Dostupné z DOI: <http://dx.doi.org/10.1016/j.celrep.2022.111238>.

Vertex Pharmaceuticals Incorporated. Vertex Announces Positive Day 90 Data for the First Patient in the Phase 1/2 Clinical Trial Dosed With VX-880, a Novel Investigational Stem Cell-Derived Therapy for the Treatment of Type 1 Diabetes. BusinessWire. Oct 18, 2021.

Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663–676. Dostupné z DOI: <http://dx.doi.org/10.1016/j.cell.2006.07.024>.

de Klerk E, Hebrok M. Stem Cell-Based Clinical Trials for Diabetes Mellitus. Front Endocrinol (Lausanne) 2021; 12: 631463. Dostupné z DOI: <http://dx.doi.org/10.3389/fendo.2021.631463>.

Zhou X, Xu Z, You Y et al. Subcutaneous device-free islet transplantation. Front Immunol 2023; 14: 1287182. Dostupné z DOI: <http://dx.doi.org/10.3389/fimmu.2023.1287182>.

Arzouni AA, Vargas-Seymour A, Nardi N et al. Using Mesenchymal Stromal Cells in Islet Transplantation. Stem Cells Transl Med 2018; 7(8): 559–563. Dostupné z DOI: <http://dx.doi.org/10.1002/sctm.18–0033>.

Shapiro AM, Thompson D, Donner TW et al. Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device. Cell Rep Med 2021; 2(12): 100466. Dostupné z DOI: <http://dx.doi.org/10.1016/j.xcrm.2021.100466>.

Parums DV. Editorial: First Regulatory Approval for Allogeneic Pancreatic Islet Beta Cell Infusion for Adult Patients with Type 1 Diabetes Mellitus. Med Sci Monit 2023; 29: e941918. Dostupné z DOI: <http://dx.doi.org/10.12659/MSM.941918>.

Vaithilingam V, Bal S, Tuch BE. Encapsulated Islet Transplantation: Where Do We Stand? Rev Diabet Stud 2017; 14(1): 51–78. Dostupné z DOI: <http://dx.doi.org/10.1900/RDS.2017.14.51>.

Kinasiewicz J, Antosiak-Iwanska M, Godlewska E et al. Effect of Over 10-Year Cryopreserved Encapsulated Pancreatic Islets Of Langerhans. Exp Clin Transplant 2018; 16(4): 461–465. Dostupné z DOI: <http://dx.doi.org/10.6002/ect.2016.0343>.

Zhang Y, Yang J, Zhang J et al. A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation. J Materials Chem B 2020; 8(21): 4627–4641. Dostupné z DOI: <http://dx.doi.org/10.1039/d0tb00561d>.

Cohrs CM, Chen C, Speier S. Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging. Methods Mol Biol 2020; 2128: 149–157. Dostupné z DOI: <http://dx.doi.org/10.1007/978–1-0716–0385–7_11>.

Cantarelli E, Melzi R, Mercalli A et al. Bone Marrow as an Alternative Site for Islet Transplantation. Blood 2009; 114(20): 4566–4574. Dostupné z DOI: <http://dx.doi.org/10.1182/blood-2009–03–209973>.

Zhan L, Rao JS, Sethia N et al. Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation. Nat Med 2022; 28: 798–808. Dostupné z DOI: <http://dx.doi.org/10.1038/s41591–022–01718–1>.

Mitsugashira H, Imura T, Inagaki A et al. Development of a novel method for measuring tissue oxygen pressure to improve the hypoxic condition in subcutaneous islet transplantation. Sci Rep 2022; 12(1): 14731. Dostupné z DOI: <http://dx.doi.org/10.1038/s41598–022–19189–2>.

Arutyunyan IV, Fatkhudinov TK, Makarov AV et al. Regenerative medicine of pancreatic islets. World J Gastroenterol 2020; 26(22): 2948–2966. Dostupné z DOI: <http://dx.doi.org/10.3748/wjg.v26.i22.2948>.

Herold KC, Bundy BN, Long SA et al. [Type 1 Diabetes TrialNet Study Group]. An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes. N Engl J Med 2019; 381(7): 603–613. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1902226>.

Quattrin T, Haller MJ, Steck AK et al. [T1GER Study Investigators]. Golimumab and beta-cell function in youth with new-onset type 1 diabetes. N Engl J Med 2020; 383(21): 2007–2017. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa2006136>.

Xu G, Chen J, Jing G et al. Preventing β-cell loss and diabetes with calcium channel blockers. Diabetes 2012; 61(4): 848–856. Dostupné z DOI: <http://dx.doi.org/10.2337/db11–0955>.

Wei Z, Yoshihara E, He N et al. Vitamin D switches BAF complexes to protect β cells. Cell 2018; 173(5): 1135–1149.e15. Dostupné z DOI: <http://dx.doi.org/10.1016/j.cell.2018.04.013>.

Farilla L, Bulotta A, Hirshberg B et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 2003; 144(12): 5149–5158. Dostupné z DOI: <http://dx.doi.org/10.1210/en.2003–0323>.

Alam S, Khan SJ, Lee CY et al. Type 1 Diabetes Mellitus Management and Islet Cell Therapy: A New Chapter in Patient Care. Cureus 2023; 15(10): e46912. Dostupné z DOI: <http://dx.doi.org/10.7759/cureus.46912>.

Labels
Diabetology Endocrinology Internal medicine
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#