Insulin therapy and cardiovascular complications

Czech version

Authors: Milan Kvapil
Authors‘ workplace: Interní klinika 2. LF UK a FN v Motole, Praha
Published in: Forum Diab 2017; 6(2): 61-66
Category: Topic

Overview

Insulin has a proatherogenic effect, endogenous hyperinsulinemia is associated with a higher cardiovascular risk. The treatment by exogenous insulin may increase cardiovascular risk due to a higher risk of hypoglycemia. This can be efficiently eliminated by using new insulin analogues. According to the ORIGIN study, the therapy by exogenous insulin analogue does not in itself increase cardiovascular risk. However insulin as ultimum refugium for patients with type 2 diabetes mellitus is a signal of the primarily increased CV risk. Therefore it is important to make every effort to slow the progression of type 2 diabetes mellitus by all means, which can be, paradoxically, also supported by a timely and safe insulin therapy.

Key words:
atherosclerosis, diabetes mellitus, ischemic heart disease, insulin, insulin analogues, mortality, stroke

Received:
28.4.2017

Accepted:
9.5.2017

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Labels

Diabetology Endocrinology Internal medicine

Insulin in the therapeutic scheme for type 2 diabetes mellitus

Factors conducive to optimal control of type 1 diabetes mellitus in childhood and adolescence

Insulin therapy in older age

Insulin therapy during pregnancy

Overinsulinization – the frequent cause of unsatisfactory glycemic control: case reports

Article was published in

Forum Diabetologicum

2017 Issue 2